trka receptor การใช้

• Binding interaction between NGF and the TrkA receptor facilitates receptor dimerization and tyrosine residue phosphorylation of the cytoplasmic tail by adjacent Trk receptors.
• In the presence of nerve growth factor ( NGF ), TrkA receptors are trafficked to the stimulated side of the growth cone.
• When NGF binds to the TrkA receptor, it drives the homodimerization of the receptor, which in turn causes the autophosphorylation of the tyrosine kinase segment.
• The gene NTRK1 ( encoding the TrkA receptor ), located on chromosome 1q, is similarly translocated in approximately 5 percent to 10 percent of papillary thyroid cancers.
• In one study, a total absence of TrkA receptor was found in keratoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.
• Trk receptor phosphorylation sites operate as Shc adaptor protein docking sites, which undergo phosphorylation by the TrkA receptor Once the cytoplasmic adaptor protein ( Shc ) is phosphorylated by the receptor cytoplasmic tail, cell survival is initiated through several intracellular pathways.